We each live in a delusion of grandeur, feeling our tiny lives have an external significance even vaguely comparable in magnitude to the huge significance our lives have to ourselves. This is an adaptive feature of human nature.
Taken to extremes, as in a manic psychotic episode, it becomes pathological. It seems to me that the falling away of that delusion would also be pathological and dangerous to survival, but I don’t know the clinical name for the condition. On the other hand, maybe overcoming that delusion is an important aspect of spiritual development, and seeing reality more clearly is not actually dangerous.